Toroidal-Spiral Particles Heading link
Toroidal-Spiral Particles
Toroidal-spiral particles droplet sedimentation kinetics and interaction Heading link
![When a polymer droplet sediments in a miscible solution, viscous forces overwhelm any small miscible interfacial tension existing between the polymer and the bulk solutions to roll up the interface into an intricate toroidal-spiral shape. This heterogeneous structure, whose length and width can be precisely manipulated by tuning the fluid dynamic parameters, presents a large surface-to-volume ratio.](https://liu.lab.uic.edu/wp-content/uploads/sites/1052/2023/12/research_1.png)
When a polymer droplet sediments in a miscible solution, viscous forces overwhelm any small miscible interfacial tension existing between the polymer and the bulk solutions to roll up the interface into an intricate toroidal-spiral shape. This heterogeneous structure, whose length and width can be precisely manipulated by tuning the fluid dynamic parameters, presents a large surface-to-volume ratio.
Co-encapsulation and delivery of antibodies and small molecular drugs Heading link
![Co-encapsulation and delivery of antibodies and small molecular drug](https://liu.lab.uic.edu/wp-content/uploads/sites/1052/2023/12/research_2-1090x348.png)
The release schedule of the compounds can be independently manipulated to reach the best drug synergy.
Therapeutic cell delivery Heading link
![The toroidal-spiral particles are designed for in vivo cell expansion and delivery.](https://liu.lab.uic.edu/wp-content/uploads/sites/1052/2023/12/research_3.jpg)
The toroidal-spiral particles are designed for in vivo cell expansion and delivery.
Nanoparticle Heading link
Nanoparticle
Scalable, continuous process to generate nanoparticles with well-controlled physicochemical and biomedical properties Heading link
![The nanoparticles are designed with cooperative features for better treatment of complex diseases. These biocompatible and biodegradable nanoparticles are synthesized with a narrow size distribution, high drug loading, and long-term stability.](https://liu.lab.uic.edu/wp-content/uploads/sites/1052/2023/12/research_5-1090x720.png)
The nanoparticles are designed with cooperative features for better treatment of complex diseases.
These biocompatible and biodegradable nanoparticles are synthesized with a narrow size distribution, high drug loading, and long-term stability.
Advanced X-ray techniques Heading link
Advanced X-ray techniques
Integration of microfluidic devices with synchrotron X-ray for the in situ detection of ultra-fast self-assembly kinetics Heading link
![The nanoparticles are designed with cooperative features for better treatment of complex diseases. These biocompatible and biodegradable nanoparticles are synthesized with a narrow size distribution, high drug loading, and long-term stability.](https://liu.lab.uic.edu/wp-content/uploads/sites/1052/2023/12/research_6.jpg)
Utilizing synchrotron small-angle X-ray scattering (SAXS) integrated with a microfluidic device, micellization kinetics of a diblock co-polymer, poly(ethylene glycol)-b-poly(caprolactone), was measured in situ with millisecond temporal and micrometer spatial resolution
Molecular packing, binding, and degradation at the gas/water interface Heading link
![Molecular packing, binding, and degradation at the interface](https://liu.lab.uic.edu/wp-content/uploads/sites/1052/2023/12/research_7-1090x789.jpg)
We investigated molecular packing, interaction, and degradation of phospholipids and enzymes using X-ray reflectivity and grazing incidence X-ray diffraction (GIXD) techniques. After enzyme-catalyzed degradation of saturated phospholipids, fatty acids together with divalent cations self-assembled into highly ordered inverted bilayer and trilayer structures.