Toroidal-Spiral Particles

Toroidal-spiral particles droplet sedimentation kinetics and interaction Heading link

When a polymer droplet sediments in a miscible solution, viscous forces overwhelm any small miscible interfacial tension existing between the polymer and the bulk solutions to roll up the interface into an intricate toroidal-spiral shape. This heterogeneous structure, whose length and width can be precisely manipulated by tuning the fluid dynamic parameters, presents a large surface-to-volume ratio.

When a polymer droplet sediments in a miscible solution, viscous forces overwhelm any small miscible interfacial tension existing between the polymer and the bulk solutions to roll up the interface into an intricate toroidal-spiral shape. This heterogeneous structure, whose length and width can be precisely manipulated by tuning the fluid dynamic parameters, presents a large surface-to-volume ratio.

Co-encapsulation and delivery of antibodies and small molecular drugs Heading link

Co-encapsulation and delivery of antibodies and small molecular drug

The release schedule of the compounds can be independently manipulated to reach the best drug synergy.

Therapeutic cell delivery Heading link

The toroidal-spiral particles are designed for in vivo cell expansion and delivery.

The toroidal-spiral particles are designed for in vivo cell expansion and delivery.

Nanoparticle

Scalable, continuous process to generate nanoparticles with well-controlled physicochemical and biomedical properties Heading link

The nanoparticles are designed with cooperative features for better treatment of complex diseases. These biocompatible and biodegradable nanoparticles are synthesized with a narrow size distribution, high drug loading, and long-term stability.

The nanoparticles are designed with cooperative features for better treatment of complex diseases.
These biocompatible and biodegradable nanoparticles are synthesized with a narrow size distribution, high drug loading, and long-term stability.

Advanced X-ray techniques

Integration of microfluidic devices with synchrotron X-ray for the in situ detection of ultra-fast self-assembly kinetics Heading link

The nanoparticles are designed with cooperative features for better treatment of complex diseases. These biocompatible and biodegradable nanoparticles are synthesized with a narrow size distribution, high drug loading, and long-term stability.

Utilizing synchrotron small-angle X-ray scattering (SAXS) integrated with a microfluidic device, micellization kinetics of a diblock co-polymer, poly(ethylene glycol)-b-poly(caprolactone), was measured in situ with millisecond temporal and micrometer spatial resolution

Molecular packing, binding, and degradation at the gas/water interface Heading link

Molecular packing, binding, and degradation at the interface

We investigated molecular packing, interaction, and degradation of phospholipids and enzymes using X-ray reflectivity and grazing incidence X-ray diffraction (GIXD) techniques. After enzyme-catalyzed degradation of saturated phospholipids, fatty acids together with divalent cations self-assembled into highly ordered inverted bilayer and trilayer structures.