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Microfluidics and Nanotechnology

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Toroidal Spiral Micro-Particles (TSMPs) self-assemble and self-load by the competitive kinetics of viscous flow, diffusion and a cross-linking reaction. The resultant spiral structure is expected to be particularly conducive to both high drug loadings and prolonged release profiles.Thus, this work represents promising new biomedical applications enabled byfundamental fluid mechanics and transport phenomena.
For extremely complex heterogeneous diseases, such as cancer and immunoinflammatory disorders, deliver of a single therapeutic agent or a simple combination of multiple therapeutic agents is not an efficient method of treatment. We aim to develop synergistic drug delivery system (SDDS) based on dynamic self-assembling nanotechnology to achieve precise control of pharmacokinetics and pharmacodynamics of multiple-drug delivery.


Microfluidics and Nanotechnology

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As for the liposomal drugs, liposome structures and physicochemical characteristics could be altered by a wide range of choices of phospholipids, polymer conjugation, and addition of membrane proteins. This flexibility permits the modification of liposome design and behavior-in-vivo according to specific therapeutic needs. However, the number of possibilities is enormous and optimization of the structure is not feasible by empirical trials. Therefore, it is necessary to investigate the mechanisms of the effects of lipids interfacial structures on the enzyme-induced hydrolysis and the strategies of controlling the hydrolysis process to design the “smart” liposomal drugs, which were exclusively released in regions where intrinsic enzymes are over-expressed due to disease or injury.

As for the liposomal drugs, liposome structures and physicochemical characteristics could be altered by a wide range of choices of phospholipids, polymer conjugation, and addition of membrane proteins. This flexibility permits the modification of liposome design and behavior-in-vivo according to specific therapeutic needs. However, the number of possibilities is enormous and optimization of the structure is not feasible by empirical trials. Therefore, it is necessary to investigate the mechanisms of the effects of lipids interfacial structures on the enzyme-induced hydrolysis and the strategies of controlling the hydrolysis process to design the “smart” liposomal drugs, which were exclusively released in regions where intrinsic enzymes are over-expressed due to disease or injury.

Alexander Donovan
adonov4@uic.edu
2008: B.S., Biological Chemistry & B.A., Chemistry (General Honors),
                   University of Chicago, Chicago, IL
Research Project: Threshold-Switchable Particles to Treat Internal Hemorrhage

Pin Zhang
pzhang30@uic.edu
2013: M.S., Safety Engineering, Nanjing University of Science & Technology,
                    Nanjing, China
2010: B.S., Safety Engineering, Nanjing University of Science & Technology,
                   Nanjing, China
Research Project: Optimization of Encapsulation of Polymeric Nanoparticles in Lipid                                Vesicles

Chang Liu
cliu209@uic.edu
2014: M.S., Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA
2013: B.S., Chemical Engineering, East China University of Science and Technology,                        Shanghai, China

Joseph Kalkowski
kalkwsk2@uic.edu
2015: B.S., Chemical Engineering, University of Illinois Chicago, IL
2012: A.A., Liberal Arts, Oakton Community College, Des Plaines, IL
Research Project: Small Angle X Ray Scattering Studies on Polymeric
                               Nanostructure Formation

Graduate Students
 

Principal Investigator 

Ying Liu
Associate Professor
Department of Chemical Engineering
Department of Biopharmaceutical Sciences
University of Illinois at Chicago

1997 – 2001 Tsinghua University, B.E.
2002 – 2007 Princeton University, Ph D.
2007 – 2008 University of Chicago, Postdoc


Office: CEB211 & CEB128            
Lab: CEB128 
Email: yingliu@uic.edu
Phone: (312) 996-8249
Fax: (312) 996-0808

Address:
Department of Chemical Engineering
Uiversity of Illinois at Chicago
810 S. Clinton St Chicago, IL, 60607


Microfluidics and Nanotechnology

homepeopleresearch publication multimediamembers onlyUndergraduate Students

Paola Leon Plata
pleonp2@uic.edu
2008: B.S., Chemical Engineering, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia
Research Project: Toroidal-Spiral Particles

Tiep Pham
tpham37@uic.edu
2013: B.S., Chemical Engineering, University of Washington, Seatle.
Research Project: Threshold-Swichable Paticles to treat Internal Hemorrhage. 
Veronica Villanueva        Carly Burken

Alumni

Ph.D.
Vishal Sharma (Wockhardt Ltd.)
Hao Shen (Dow Agroscience)
Magdalena Szymusiak (Konvoy Pharmaceutical Tech)

M.S.
Catalina Mogollon (Randstad Life Sciences)
Yuan Zhang (Sinopec)
Ross Ransom (AbbVie)
Pei-Tzu Lin 

B.S.
Paulina Ciupinski
Amatul Salam
Matthew Kubik
Ryan Rock
Kike Buari
Matthew Levy
Thinh Tang
Charu Saini
Marzena Zarycki
Paulina Mlynarska
Sule Alabi
Daniyal Qamar
Ajayi Oluwagoke T.
Tania Wilson
Sai Bhalerao
Alex Ourth
Ebin Joseph

Post-doctoral Associate 

Magdalena Szymusiak
mrafac3@uic.edu

Senior Researcher at Liu Lab  
Associate Director of Nanomedicine Discovery at Konvoy Pharmaceutical Technology (subsidiary of KPC Pharmaceuticals)

2010: B.S., Chemical Engineering, University of Illinois at Chicago, Chicago, IL. 
2016: Ph.D., Chemical Engineering, University of Illinois at Chicago, Chicago, IL.

Recent Publications:

25. Magdalena Szymusiak, Xiaoyu Hu, Paola A. Leon Plata, Paulina Ciupinski, Zaijie Jim Wang, Ying Liu. Bioavailability of curcumin and curcumin glucuronide in the central nervous system of mice after oral delivery of nano-curcumin. International Journal of Pharmaceutics. 511(1), 415-423, 2016.

24. Alexander J. Donovan, Joseph Kalkowski, Magdalena Szymusiak, Canhui Wang, Stephanie A. Smith, Robert F. Klie, James H. Morrissey, and Ying Liu. Artificial Dense Granules: A Procoagulant Liposomal Formulation Modeled after Platelet Polyphosphate Storage Pools. Biomacromolecules. 17(8), 2572-2581, 2016.

23. Xiaoyu Hu, Fang Huang, Magdalena Szymusiak, Ying Liu, abd Zaijie Wang, Curcumin Reverses Opioid-Induced Hyperalgesia via Spinal Inhibition of CaMKIIa, PLOS ONE, 11.1, e0146393, 2016.

22. Ju Hun Yeon, Nima Mazinani, Travis S. Schlappi, Karen Y.T. Chan, James R. Baylis, Stephanie A. Smith, Alexander J. Donovan, Damien Kudela, Galen D. Stucky, Ying Liu, James H. Morrissey, Rustem F. Ismagilov, and Christian J. Kastrup, Localization of short-chain polyphosphate enhances its ability to clot flowing blood plasma, Submitted to J. Thromb. Haemost.

21. Magdalena Szymusiak*, Alexander J. Donovan*, Stephanie A. Smith, Ross Ransom, Hao Shen, Joseph Kalkowski, James H. Morrissey, and Ying Liu, Colloidal confinement of polyphosphate on gold nanoparticles robustly activates the contact pathway of blood coagulation, Bioconjugate Chem. 27 (1), 102–109, 2016. (*: These authors contributed equally to this work).

20. Xiaoyu Hu, Fang Huang, Magdalena Szymusiak, Ying Liu and Zaijie Jim Wang, Curcumin attenuates opioid tolerance and dependence by inhibiting CaMKIIα activity, Journal of Pharmacology and Experimental Therapeutics, 352 (3), 420-428, 2015.

19. Alexander J. Donovan, Joseph Kalkowski, Stephanie A. Smith, James H. Morrissey and Ying Liu, Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting, Biomacromolecules, 15 (11), 3976-3984, 2014.

18. Suzanne D'Addio, Venkata Reddy, Ying Liu, Leo Einck, and Robert K. Prud'homme, Antitubercular nanoparticle combination products: formulation strategies and in vitro efficacy for rifampicin and SQ641. Mol. Pharmaceutics, 2015, 12 (5), 1554–1563.

17. Vishal Sharma, Melanie Kollmer, Magdalena Szymusiak, Ludwig C. Nitsche, Richard A. Gemeinhart, and Ying Liu, Toroidal-spiral particles for co-delivery of anti-VEGFR-2 antibody and irinotecan-- a potential impant to hinder recurrence of glioblastoma multiforme. Biomacromolecules, 15 (3), 756-762, 2014.

16. Hao Shen, Xiaoyu Hu, Magdalena Szymusiak, Zaijie Jim Wang, and Ying Liu, Orally Administrated Nano-curcumin to Attenuate Morphine Tolerance and Dependence: Comparison between Negatively Charged PLGA and Partially and Fully PEGylated Nanoparticles. Molecular Pharmaceutics, 10 (12), 4546-4551, 2013.

15. Aryamitra A. Banerjee*, Hao Shen*, Mathew Hautman, Jaseem Anwer, Seungpyo Hong, Izet M. Kapetanovic, Ying Liu, and Alexander V Lyubimov, Polymeric nanoparticles enhance oral bioavailability of the hydrophobic chemopreventive agent (SR13668) in beagle dogs, Current Pharmaceutical Biotechnology, 14, 464-469, 2013. (*Equivalent first authors).

14. Suhair Sunoqrot, Ying Liu, Dong-Hwan Kim and Seungpyo Hong, In vitro evaluation of dendrimer-polymer hybrid nanoparticles on their controlled cellular targeting kinetics, Molecular Pharmaceutics, 10, 2157-2166, 2013.

13. Hao Shen, Aryamitra A. Banerjee, Paulina Mlynarska, Mathew Hautman, Seungpyo Hong, Izet M. Kapetanovic, Alexander V. Lyubimov, and Ying Liu, Enhanced oral bioavailability of a cancer preventive agent (SR13668) by employing polymeric nanoparticles with high drug loading, Journal of Pharmaceutical Sciences, 101 (10) 3877-3885, 2012. 

12. Magdalena Szymusiak, Vishal Sharma, Ludwig C. Nitsche, and Ying Liu, Interaction of sedimenting drops in a miscible solution – formation of heterogeneous toroidal-spiral particles, Soft Matter, 8 (29), 7556 - 7559, 2012. 

11. Suhair Sunoqrot, Jin Woo Bae, Ryan M. Pearson, Kevin Shyu, Ying Liu, Donghwan Kim, and Seungpyo Hong, Temporal Control over Cellular Targeting through Hybridization of Folate-targeted Dendrimers and PEG-PLA Nanoparticles. Biomacromolecules, 13 (4), 1223–1230, 2012. 

10. Vishal Sharma, Magdalena Szymusiak, Hao Shen, Ludwig C. Nitsche, and Ying Liu, Formation of Polymeric Toroidal-Spiral Particles, Langmuir, 28 (1), 729–735, 2012. 

9. Hao Shen, Seungpyo Hong, Robert K. Prud’homme, and Ying Liu, Self-Assembling Process of Flash NanoPrecipitation in a Multi-Inlet Vortex Mixer (MIVM) to Produce Drug-Loaded Polymeric Nanoparticles, Journal of Nanoparticle Research, 13 (9), 4109-4120, 2011. 

8. Suhair Sunoqrot, Jin Woo Bae, Su-Eon Jin, Ryan M. Pearson, Ying Liu, and Seungpyo Hong, Kinetically Controlled Cellular Interactions of Polymer−Polymer and Polymer−Liposome Nanohybrid Systems, Bioconjugate Chemistry, 22 (3), 466–474, 2011. 

7. Boris. Russ, Ying Liu, and Robert K. Prud’homme, Optimized Descriptive Model for Micromixing in a Vortex Mixer, Chemical Engineering Communications, 197 (8), 1068-1075, 2010. 

6. Ying Liu and R. Ismagilov, Dynamics of coalescence of plugs with a hydrophilic wetting layer induced by flow in a microfluidic chemistrode, Langmuir,25 (5), 2854-2859, 2009. 

5. D. Chen*, W. Du*, Ying Liu*, W. Liu*, and R. Ismagilov, The Chemistrode: a Droplet-based Microfluidic Device for Stimulation and Recording with High Temporal, Spatial, and Chemical Resolution, Proceedings of the National Academy of Sciences (PNAS), 105 (44), 16843-16848, 2008. 

4. F. Shen, C. Kastrup, Ying Liu, and R. Ismagilov, Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries is Controlled by Shear Rate, Arteriosclerosis Thrombosis and Vascular Biology, 28, 2035-2041, 2008. 

3. Ying Liu, C. Chen, R. Prudhomme, and R. Fox, Mixing in a Multi-Inlet Vortex Mixer (MIVM) for Flash Nano-Precipitation, Chemical Engineering Science, 63 (11), 2829-2842, 2008.

2. Ying Liu, Z. Tong, and R. Prudhomme, Stabilized Polymeric Nanoparticles for Controlled and Efficient Release of Bifenthrin, Pest Management Science, 64 (8), 808-812, 2008. 

1. Ying Liu, K. Kathan, W. Saad, and R. Prud’homme, Ostwald Ripening of beta-carotene Nanoparticles, Physical Review Letters, 98 (3): Art. No. 036102, 2007. 

Patents:

3. Robert K. Prud’homme, Marian Gindy, Baris Ungun, Stephanie Budijono, and Ying Liu, Nanoparticles for Photodynamic therapy, WO/2009/061406.

2. Ludwig C. Nitsche and Ying Liu, Self-assembled Toroidal-spiral Particles and manufacture and Uses Thereof, WO/2011/062936.

1. Seungpyo Hong and Ying Liu, Nano-hybrid Delivery System for Sequential Utilization of Passive and active Targeting. WO/2011/133617.

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Microfluidics and Nanotechnology

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